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  • The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, provided that they also have problems with weight-related health problems such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight management for people who are obese or are overweight and possess at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes indicated that patients had the average weight loss of four years old.1% rather than participants who were given placebos) throughout a 12- month period, while a separate study involving patients with diabetes had a normal weight loss of 2% over treatment with placebo at 12 months.

    Using two separate drugs to shed weight can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err assisting caution and permit the FDA do its job and demand some investigation be done so your public knows the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on his or her medications.

    Researchers discovered that participants using this drug for a year, dropped a few pounds within a month and have kept the weight off throughout the 56 weeks of the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which might be made up of many active ingredient, which might make them more efficient and safer.

    Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular is the fact that since right now there aren't long term prescription slimming capsules that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures can be a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure and heartbeat, and really should not be used in individuals with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not be used in patients with uncontrolled high blood pressure, in addition to by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.

    BioCorRx, Inc.'s naltrexone implant isn't bigger than a thumb which is inserted underneath the patient's skin through a 30-minute, minimally invasive outpatient procedure made by a health care professional. The implant is administered as part of BioCorRx, Inc.'s Start Fresh Program that is distributed in a number of states by independent rehabilitation facilities.